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- Title
High incidence of mutations in BRCA1 and BRCA2 genes in ovarian cancer.
- Authors
T. Smirnova; N. Pospekhova; L. Lyubchenko; S. Tjulandin; R. Gar’kavtseva; E. Ginter; A. Karpukhin
- Abstract
Abstract The incidence of mutations in the BRCA1 and BRCA2 genes in the studied sampling of 74 patients with ovarian cancer was 19%. The incidence of mutations in the Russian sampling of patients, formed without consideration for the family history, is one of the highest in European countries. Retrospective analysis showed that 9% patients carrying mutation had no family history of ovarian or breast cancer. The majority of mutations (86%) were detected in BRCA1 gene, where 5382insC mutation predominated (58%). These data suggest the possibility and advisability of screening for mutations in the BRCA1/2 genes in patients with ovarian cancer, particularly because this population includes patients without family history of ovarian and/or breast cancer.
- Subjects
GENETIC mutation; OVARIAN cancer; GENEALOGY; CANCER genetics
- Publication
Bulletin of Experimental Biology & Medicine, 2007, Vol 144, Issue 1, p83
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-007-0261-1