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- Title
PGD for fragile X syndrome: ovarian function is the main determinant of success.
- Authors
Tsafrir, Avi; Altarescu, Gheona; Margalioth, Ehud; Brooks, Baruch; Renbaum, Paul; Levy-Lahad, Ephrat; Rabinowitz, Ron; Varshaver, Irit; Eldar-Geva, Talia
- Abstract
BACKGROUND: PGD for fragile X syndrome (FRAX) is inefficient, probably owing to fewer oocytes, poor embryo quality and difficulties in genetic analysis. We investigated IVF–PGD in FRAX mutation carriers compared with controls, looking at the effects of oocyte and embryo number/quality on live birth outcome.
- Subjects
FRAGILE X syndrome; TRINUCLEOTIDE repeats; GENETIC mutation; OVUM physiology; HUMAN chromosome abnormality diagnosis
- Publication
Human Reproduction, 2010, Vol 25, Issue 10, p2629
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/deq203