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- Title
Antiplatelet drugs and liver fibrosis.
- Authors
ZHAO Xin; LI Hui; DENG Xiuxiu; TAO Yujing
- Abstract
The essence of hepatic fibrosis is the imbalance of the formation and degradation of extracellular matrix in the liver tissue. Hepatic fibrosis is a necessary stage for the progression of various chronic liver diseases to cirrhosis. Early inhibition of the occurrence and development of hepatic fibrosis is very important in the treatment of liver diseases. Platelets release a variety of cytokines, which promote hepatocyte proliferation and liver parenchyma regeneration while activating endothelial cells, inducing leukocyte recruitment, aggravating microvascular dysfunction, and participating in the process of liver fibrosis. In this paper, the research progress of antiplatelet drugs in hepatic fibrosis is reviewed, in order to provide new diagnosis and treatment ideas for hepatic fibrosis.
- Subjects
HEPATIC fibrosis; PLATELET aggregation inhibitors; LIVER diseases; LIVER regeneration; MICROCIRCULATION disorders
- Publication
Journal of Practical Medicine / Shiyong Yixue Zazhi, 2024, Vol 40, Issue 8, p1083
- ISSN
1006-5725
- Publication type
Article
- DOI
10.3969/j.issn.1006-5725.2024.08.011