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- Title
Modulatory effects of noradrenergic and serotonergic signaling pathway on neurovascular coupling.
- Authors
Renden, Robert B.; Institoris, Adam; Sharma, Kushal; Tran, Cam Ha T.
- Abstract
Dynamic changes in astrocyte Ca2+ are recognized as contributors to functional hyperemia, a critical response to increased neuronal activity mediated by a process known as neurovascular coupling (NVC). Although the critical role of glutamatergic signaling in this process has been extensively investigated, the impact of behavioral state, and the release of behavior-associated neurotransmitters, such as norepinephrine and serotonin, on astrocyte Ca2+ dynamics and functional hyperemia have received less attention. We used two-photon imaging of the barrel cortex in awake mice to examine the role of noradrenergic and serotonergic projections in NVC. We found that both neurotransmitters facilitated sensory stimulation-induced increases in astrocyte Ca2+. Interestingly, while ablation of serotonergic neurons reduced sensory stimulation-induced functional hyperemia, ablation of noradrenergic neurons caused both attenuation and potentiation of functional hyperemia. Our study demonstrates that norepinephrine and serotonin are involved in modulating sensory stimulation-induced astrocyte Ca2+ elevations and identifies their differential effects in regulating functional hyperemia. Noradrenergic and serotonergic signaling are involved in modulating sensory stimulation-induced astrocyte Ca2+ dynamics, and each signaling pathway alters functional hyperemia differently.
- Subjects
CELLULAR signal transduction; LOCUS coeruleus; NORADRENERGIC neurons; RAPHE nuclei; SEROTONIN receptors; HYPEREMIA; SENSORY neurons; NORADRENALINE
- Publication
Communications Biology, 2024, Vol 7, Issue 1, p1
- ISSN
2399-3642
- Publication type
Article
- DOI
10.1038/s42003-024-05996-y