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- Title
Targeting liver X receptors in cancer therapeutics.
- Authors
Lin, Chin-Yo; Gustafsson, Jan-Åke
- Abstract
Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors (LXRs) are nuclear receptor family members that function in cholesterol transport, glucose metabolism and the modulation of inflammatory responses. There is now accumulating evidence to support the involvement of LXRs in a variety of malignancies and the potential efficacy of their ligands in these diseases. This Review summarizes the discovery and characterization of LXRs and their ligands, their effects and mechanisms in preclinical cancer models, and the future directions of basic and translational LXR research in cancer therapeutics.
- Subjects
NUCLEAR receptors (Biochemistry); TRANSCRIPTION factors; LIGANDS (Biochemistry); CANCER treatment; GLUCOSE metabolism
- Publication
Nature Reviews Cancer, 2015, Vol 15, Issue 4, p216
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc3912