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- Title
Tumour suppressors: Different roads to inactivation.
- Authors
Seton-Rogers, Sarah
- Abstract
The article reports on a study by L. T. McGillicuddy and colleagues which suggests that understanding the mechanisms by which tumour suppressor gene NF1 is inactivated may have therapeutic implications. Researchers determine whether signalling pathways destabilize NF1 in sporadic tumours. They discover that preventing expression of NF1 induced p53-dependent senescence and conclude that protein kinase C can be a therapeutic target in glioblastomas.
- Subjects
TUMOR suppressor genes; PROTEIN kinase C; GENE expression; GLIOBLASTOMA multiforme treatment; TUMOR genetics; MCGILLICUDDY, L. T.; THERAPEUTICS; PROTEIN metabolism; PROTEINS; GENETIC mutation; ONCOGENES; GLIOMAS
- Publication
Nature Reviews Cancer, 2009, Vol 9, Issue 9, p610
- ISSN
1474-175X
- Publication type
journal article
- DOI
10.1038/nrc2719