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- Title
Antibiotic Therapy for Prosthetic Joint Infections: An Overview.
- Authors
Le Vavasseur, Benjamin; Zeller, Valérie
- Abstract
Prosthetic joint infection (PJI) is a severe complication after arthroplasty. Its management combines surgical intervention, whose type depends on the clinical situation, and prolonged high-dose antibiotics adapted to the responsible microorganism(s) and the patient. Antibiotics are only one part of the therapeutic regimen and are closely related to the surgical strategy. Their efficacy depends to a large extent on the choice and quality of the surgical procedure, and the quality of the microbiological diagnosis. Although guidelines have been published, many aspects of antibiotic therapy remain poorly established. Choosing the optimal agent(s) is one aspect, with others being optimization of drugs' pharmacokinetic/pharmacodynamic parameters, the choice of administration route, use of monotherapy or combination regimens, therapeutic drug-monitoring and patient education to improve compliance and tolerance. Herein, we address PJI management based on recent literature data, guidelines and the experience of our referral center for complex bone-and-joint infections.
- Subjects
ARTIFICIAL joints; JOINT infections; ANTIBIOTICS; ROUTE choice; PATIENT education; OPERATIVE surgery
- Publication
Antibiotics (2079-6382), 2022, Vol 11, Issue 4, pN.PAG
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics11040486