We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children.
- Authors
Lodi, Lorenzo; Ricci, Silvia; Nieddu, Francesco; Moriondo, Maria; Lippi, Francesca; Canessa, Clementina; Mangone, Giusi; Cortimiglia, Martina; Casini, Arianna; Lucenteforte, Ersilia; Indolfi, Giuseppe; Resti, Massimo; Azzari, Chiara
- Abstract
The effectiveness and impact of the 13-valent pneumococcal conjugate vaccine (PCV13) against invasive pneumococcal diseases (IPD) due to serotype 3 (ser3) has been questioned. However, the impact of PCV13 on different clinical presentations of ser3-IPD has not been studied so far. The impact of PCV13 on different clinical presentations of ser3-IPD in a population of Italian children aged 0–8 years was evaluated, comparing pre- and post-PCV13 introduction period. Real-time polymerase chain reaction (PCR) was used for the diagnosis and serotyping of IPD. During the observation period (1 January 2006–1 August 2018), ser3 was detected in 60/284 (21.1%) children under 8 with serotyped IPD. The incidence of sepsis and meningitis was 0.24 per 1,000,000 person-years (p-y) in pre-PCV13 and 0.02 per 1,000,000 p-y in post-PCV13. No cases occurred in vaccinated children. In the post-PCV13 period, case reduction was 13% for all ser3 IPD and 92% for sepsis and meningitis. Vaccination impact may be underestimated due to significant improvement in pneumococcal surveillance in post-PCVC13. Our data suggest a significant impact of PCV13 on meningitis and sepsis due to ser3 and a lower impact against pneumonia. While waiting for increasingly effective anti-pneumococcal vaccines, PCV13, which guarantees protection against the most severe clinical presentations of ser3-IPD, is currently the most effective prevention option available.
- Subjects
PNEUMOCOCCAL vaccines; STREPTOCOCCUS pneumoniae; POLYMERASE chain reaction; VACCINATION; MENINGITIS
- Publication
Vaccines, 2019, Vol 7, Issue 4, p128
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines7040128