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- Title
Recovery of deepening of the upper eyelid sulcus after switching from prostaglandin FP receptor agonists to EP2 receptor agonist: a 3-month prospective analysis.
- Authors
Sakata, Rei; Fujishiro, Takashi; Saito, Hitomi; Nakamura, Natsuko; Honjo, Megumi; Shirato, Shiroaki; Miyamoto, Etsuyo; Yamada, Yoshiaki; Aihara, Makoto
- Abstract
Purpose: To examine the effect of switching from a prostanoid FP receptor agonists to EP2 receptor agonist (omidenepag isopropyl) on the deepening of the upper eyelid sulcus (DUES) and intraocular pressure (IOP) in Japanese glaucoma patients over 3 months post treatment. Study design: Prospective observational study. Methods: Patients with glaucoma who received FP receptor agonists treatment and had complained of DUES-related reduction in quality of life were included. Their FP receptor agonists was switched to omidenepag isopropyl without a drug holiday. At baseline and 1 and 3 months post-switch, photographs were taken and the changes in DUES were assessed by three independent observers. IOP and adverse events were also assessed. Results: The study included 23 eyes of 23 patients (6 men, 17 women; average age, 60.6 years). After switching, DUES improved in 12 eyes at 1 month and in 16 eyes at 3 months; eyes in the remaining patients showed no worsening of the condition. The mean IOP before switching was 15.3 ± 3.3 mmHg (95% confidence interval 13.9–16.7 mmHg). Following the switch, the mean IOP values were 15.6 ± 3.3 mmHg (14.1–17.0 mmHg) at 1 month and 15.5 ± 3.3 mmHg (14.1–16.9 mmHg) at 3 months (P = 1.0 at 1 month, P = 1.0 at 3 months; both adjusted by Bonferroni correction). No adverse effects were observed. Conclusion: Omidenepag isopropyl improved DUES while maintaining IOP in over 70% of Japanese patients with glaucoma who exhibited DUES caused by FP receptor agonists; the improvement was observed within 3 months after switching from FP receptor agonists.
- Subjects
PROSTAGLANDIN receptors; EYELIDS; INTRAOCULAR pressure; JAPANESE people; BONFERRONI correction
- Publication
Japanese Journal of Ophthalmology, 2021, Vol 65, Issue 5, p591
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-021-00855-3