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- Title
Changes of enterogenous 5-HT and bone mineral density after the intervention of traditional Chinese medicine and western medicine.
- Authors
DENG Weimin; ZHANG Jinhe; LIU Ze; ZHANG Yasong; KANG Luchen
- Abstract
Objective To observe the effect of the nourishing kidney and strengthening bone granule and alendronate on the changes of enterogenous 5-hydroxytryptamine (5-HT) and bone mineral density (BMD) in patients with osteoporosis (OP), and to explore its mechanism. Methods One hundred and tewenty patients with primar)' OP, who came to the inpatient and outpatient department in the Gencnral Hospital of PLA Guangzhou Militar)' Area from May 2011 to December 2012, were selected. All the patients were divided into the nourishing kidney and strengthening bone granule group and alendronate group. After 12-hour fasting. 3ml fasting venous blood of each patient was collected during 80-00-9:00 am The blood was instantly centrifuged (3000 r/min) for 5 min. and the serum was stored in a -SOX refrigerator. The concentration of 5-HT in the serum was determined using ELISA. BMD of each part was detected using the dual energy X-ray absorptiometry (DEXA, Lunar Prodigy, GE Co., USA). The changes of 5-HT and BMD before and after the treatment were analyzed. The serum concentrations of P1NP. β-Crosslaps. and PTH were detected asing eleclrochemilumincscence immunoassay. Results BMD of the left femoral neck, the Ward's triangle, and the left proximal femur increased in the the nourishing kidney and strengthening bone granule group after the treatment, while the serum levels of 5-HT, P1NP. G-Crosslaps, and PTH decreased. In alendronate group, except for BMD of the lumbar vertebrae, BMD of the rest parts increased obviously after the treatment. And the serum levels of 5-HT, PINP, (B-Crosslaps, and PTH also decreased. According to the comparison of the related indexes between the nourishing kidney and strengthening bone granule group and alendronate group after the treatment, no significant difference of BMD between the two groups was observed. The changes of the bone metabolic indexes between the two groups before and after treatment also showed no significant differenc. Conclusion The nourishing kidney and strengthening bone granule and alendronate sodium can both increase BMD and reduce the enterogenous 5-HT concentration, and it is coincide with Ulrike' s theory that gut-derived 5-HT was negatively related with BMD.
- Publication
Chinese Journal of Osteoporosis, 2014, Vol 20, Issue 8, p913
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2014.08.0011