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- Title
新型气体信号分子H<sub>2</sub>S与骨质疏松的研究概况.
- Authors
宗群川; 王涛
- Abstract
Osteoporosis continues to be a major health problem worldwide. Understanding the exact mechanism and influencing factors of bone metabolism is a major research focus. H2S has been widely recognized as a novel endogenous gas signaling molecule and has been found to be an important modulator of bone homeostasis. It has been found that H2S inhibits the oxidative stress, regulates the Ca2+ channel of bone mesenchymal cells, promotes the activity of specific matrix metalloproteinase( MMP), regulates the balance of bone metabolism, and thus prevents and treats postmenopausal and long-term use of glucocorticoids-induced osteoporosis. From the study of the mechanism of endogenous H2S, H2S experimental study of exogenous donor is also gradually carried out. In this paper, the existing studies are summarized for further research.
- Subjects
OSTEOPOROSIS diagnosis; BONE metabolism; HOMEOSTASIS; ENDOGENOUS hydrogen sulfide; METALLOPROTEINASE regulation
- Publication
Chinese Journal of Osteoporosis, 2017, Vol 23, Issue 10, p1396
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2017.10.027