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- Title
Efficacy and tolerability of lamivudine plus dolutegravir as a switch strategy in a multicentre cohort of patients with suppressed HIV‐1 replication.
- Authors
Borghetti, A.; Baldin, G.; Lombardi, F.; Ciccullo, A.; Capetti, A.; Rusconi, S.; Sterrantino, G.; Latini, A.; Cossu, M. V.; Gagliardini, R.; De Luca, A.; Di Giambenedetto, S.
- Abstract
Objectives: We evaluated the efficacy and tolerability of lamivudine + dolutegravir in a cohort of HIV‐1 infected, treatment‐experienced patients with undetectable HIV‐RNA. Methods: Time to treatment discontinuation (TD) and virological failure (VF) and their predictors were assessed in a multicenter cohort of HIV‐1 infected patients, starting lamivudine + dolutegravir after reaching viral suppression. Secondary objective was the evaluation of changes in lipid profile, renal and immunological functions at week 48. Results: We enrolled 206 patients (72.8% male, with 51 years median age), who mainly switched their antiretroviral therapy for simplification (32.5%) or drug toxicity (54.5%). The estimated probability of maintaining virological suppression at 48 and 96 weeks was 98.2% and 95.1%, respectively. VF was independently predicted by cumulative time on antiretroviral therapy. The estimated probability of remaining on lamivudine plus dolutegravir was 86.7% and 80.5% at week 48 and 96, respectively. A significant improvement in immunological function (CD4 count and CD4/CD8 ratio) was evidenced at week 48, as well as a decrease in total cholesterol/HDL ratio, triglycerides and estimated glomerular filtration rate. Conclusions: Lamivudine plus dolutegravir was effective in maintaining viral suppression in our cohort and led to an improvement in metabolic and immunologic functions.
- Subjects
KIDNEY physiology; ANTIRETROVIRAL agents; LAMIVUDINE; LIPID analysis; ANTIGENS; CHOLESTEROL; DRUG tolerance; GLOMERULAR filtration rate; HIGH density lipoproteins; HIV; HIV infections; LONGITUDINAL method; MEDICAL cooperation; MEDICAL prescriptions; PROBABILITY theory; RESEARCH; STRATEGIC planning; TOXICITY testing; TRIGLYCERIDES; VIRAL load; TERMINATION of treatment; TREATMENT effectiveness; THERAPEUTICS
- Publication
HIV Medicine, 2018, Vol 19, Issue 7, p452
- ISSN
1464-2662
- Publication type
Article
- DOI
10.1111/hiv.12611