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- Title
Immunohistochemical expression of bone morphogenetic protein-2 in pilomatricoma.
- Authors
Kurokawa, I.; Kusumoto, K.; Bessho, K.; Okubo, Y.; Senzaki, H.; Tsubura, A.
- Abstract
Background The mechanism of occurrence of calcification and ossification in pilomatricoma remains unclear. Objectives To elucidate the pathogenesis of calcification and ossification in pilomatricoma we examined the role of bone morphogenetic protein (BMP)-2, which plays important parts in inducing ectopic bone formation both in vivo and in vitro. Methods Twenty cases of pilomatricoma were studied immunohistochemically using anti-BMP-2 monoclonal antibody. Results In normal skin, including hair follicles, there was no BMP-2 expression. In all pilomatricomas, BMP-2 was found exclusively in the cytoplasm of shadow cells but not in basophilic cells. In two cases of bone formation seen in pilomatricoma, osteoblasts in the periosteal area showed a strong positive reaction, while bone trabeculum (bone matrix) showed no reaction. Conclusions Our findings indicate that shadow cells positive for BMP-2 may play an important part in generating bone formation in pilomatricoma.
- Subjects
BONE morphogenetic proteins; MONOCLONAL antibodies; CALCIFICATION; OSSIFICATION
- Publication
British Journal of Dermatology, 2000, Vol 143, Issue 4, p754
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1046/j.1365-2133.2000.03771.x