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- Title
The Roles of circRNAs in Liver Cancer Immunity.
- Authors
Tang, Ying; Jiang, Mei; Jiang, Hai-Mei; Ye, Zeng Jie; Huang, Yu-Sheng; Li, Xiu-Shen; Qin, Bin-Yu; Zhou, Rui-Sheng; Pan, Hua-Feng; Zheng, Da-Yong
- Abstract
Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized the functions of circRNAs in liver cancer, including proliferative, metastasis and apoptosis, liver cancer stemness, cell cycle, immune evasion, glycolysis, angiogenesis, drug resistance/sensitizer, and senescence. Immune escape is considered to be one of the hallmarks of cancer development, and circRNA participates in the immune escape of liver cancer cells by regulating natural killer (NK) cell function. CircRNAs may provide new ideas for immunotherapy in liver cancer.
- Subjects
LIVER cancer; KILLER cells; LIVER cells; CIRCULAR RNA; NON-coding RNA
- Publication
Frontiers in Oncology, 2021, Vol 11, pN.PAG
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2020.598464