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- Title
Pneumococcal immune evasion: ZmpC inhibits neutrophil influx.
- Authors
Surewaard, Bas G. J.; Trzciński, Krzysztof; Jacobino, Shamir R.; Hansen, Ivo S.; Vughs, Mignon M.; Sanders, Elisabeth A. M.; Ende, Arie; Strijp, Jos A. G.; Haas, Carla J. C.
- Abstract
Neutrophil recruitment is essential in clearing pneumococcal infections. The first step in neutrophil extravasation involves the interaction between P-selectin on activated endothelium and P- Selectin Glycoprotein 1 ( PSGL-1) on neutrophils. Here, we identify pneumococcal Zinc metalloproteinase C as a potent inhibitor of PSGL-1. ZmpC degrades the N-terminal domain of PSGL-1, thereby disrupting the initial rolling of neutrophils on activated human umbilical vein endothelial cells. Furthermore, mice infected with wild-type strain in the model of pneumococcal pneumonia showed lower lungs neutrophil infiltration compare to animals infected with ZmpC mutant. In addition, we confirmed the association of zmpC with serotype 8 and 11 A and found it to be associated with serotype 33 F as well. In conclusion, wereport PSGL-1 as a novel target for ZmpC and show that ZmpC inhibits neutrophil extravasation during pneumococcal pneumonia.
- Subjects
PNEUMOCOCCAL meningitis; IMMUNE response; NEUTROPHILS; METALLOPROTEINASES; EXTRAVASATION; UMBILICAL veins; ENDOTHELIAL cells
- Publication
Cellular Microbiology, 2013, Vol 15, Issue 10, p1753
- ISSN
1462-5814
- Publication type
Article
- DOI
10.1111/cmi.12147