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- Title
Fast time-domain diffuse correlation spectroscopy with superconducting nanowire single-photon detector: system validation and in vivo results.
- Authors
Parfentyeva, Veronika; Colombo, Lorenzo; Lanka, Pranav; Pagliazzi, Marco; Brodu, Annalisa; Noordzij, Niels; Kolarczik, Mirco; Dalla Mora, Alberto; Re, Rebecca; Contini, Davide; Torricelli, Alessandro; Durduran, Turgut; Pifferi, Antonio
- Abstract
Time-domain diffuse correlation spectroscopy (TD-DCS) has been introduced as an advancement of the "classical" continuous wave DCS (CW-DCS) allowing one to not only to measure depth-resolved blood flow index (BFI) but also to extract optical properties of the measured medium without using any additional diffuse optics technique. However, this method is a photon-starved technique, specially when considering only the late photons that are of primary interest which has limited its in vivo application. In this work, we present a TD-DCS system based on a superconducting nanowire single-photon detector (SNSPD) with a high quantum efficiency, a narrow timing response, and a negligibly low dark count noise. We compared it to the typically used single-photon avalanche diode (SPAD) detector. In addition, this system allowed us to conduct fast in vivo measurements and obtain gated pulsatile BFI on the adult human forehead.
- Subjects
NANOWIRES; TERAHERTZ spectroscopy; AVALANCHE diodes; DETECTORS; QUANTUM efficiency; SPECTROMETRY; PHOTOCATHODES
- Publication
Scientific Reports, 2023, Vol 13, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-023-39281-5