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- Title
Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus.
- Authors
Maeda, Shiro; Tsukada, Shuichi; Kanazawa, Akio; Sekine, Akihiro; Tsunoda, Tatsuhiko; Koya, Daisuke; Maegawa, Hiroshi; Kashiwagi, Atsunori; Babazono, Tetsuya; Matsuda, Masafumi; Tanaka, Yasushi; Fujioka, Tomoaki; Hirose, Hiroshi; Eguchi, Takashi; Ohno, Yoichi; Groves, Christopher; Hattersley, Andrew; Hitman, Graham; Walker, Mark; Kaku, Kohei
- Abstract
To search a gene(s) conferring susceptibility to type 2 diabetes mellitus, we genotyped nearly 60,000 gene-based SNPs for Japanese patients and found evidence that the gene at chromosome 6p12 encoding transcription-factor-activating protein 2β ( TFAP2B) was a likely candidate in view of significant association of polymorphism in this gene with type 2 diabetes. Extensive analysis of this region identified that several variations within TFAP2B were significantly associated with type 2 diabetes [a variable number of tandem repeat locus: χ2=10.9, P=0.0009; odds ratio=1.57, 95% CI 1.20–2.06, intron 1+774 (G/T); χ2=11.6, P=0.0006; odds ratio=1.60, 95% CI 1.22–2.09, intron 1+2093 (A/C); χ2=12.2, P=0.0004; odds ratio=1.61, 95% CI 1.23–2.11]. The association of TFAP2B with type 2 diabetes was also observed in the UK population. These results suggest that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 diabetes.
- Subjects
JAPAN; TYPE 2 diabetes; GENETICS of diabetes; TRANSCRIPTION factors; GENETIC polymorphisms; ENDOCRINE diseases
- Publication
Journal of Human Genetics, 2005, Vol 50, Issue 6, p283
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s10038-005-0253-9