We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the human nuclear factor kappa-beta subunit 1 (NFKB1) locus.
- Authors
Ota, Nobutaka; Nakajima, Toshiaki; Shirai, Yasumasa; Emi, M.
- Abstract
Abstract The transcriptional factor nuclear factor kappa-beta (NFKB) consists of a multicomponent protein complex that plays a major role in the regulation of many viral and cellular genes. The NFKB complex has two alternative DNA binding subunits. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the NFKB subunit 1 (NFKB1) gene located at 4q23-24. High heterozygosity (0.813) makes this polymorphism a useful marker in the genetic study of disorders affecting the immune response and cell differentiation.
- Subjects
NF-kappa B; NUCLEOTIDES; IMMUNE response; CELL differentiation
- Publication
Journal of Human Genetics, 1999, Vol 44, Issue 2, p129
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380050125