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- Title
Global Distribution of Human Protoparvoviruses.
- Authors
Väisänen, Elina; Mohanraj, Ushanandini; Kinnunen, Paula M.; Jokelainen, Pikka; Al-Hello, Haider; Barakat, Ali M.; Sadeghi, Mohammadreza; Jalilian, Farid A.; Majlesi, Amir; Masika, Moses; Mwaengo, Dufton; Anzala, Omu; Delwart, Eric; Vapalahti, Olli; Hedman, Klaus; Söderlund-Venermo, Maria
- Abstract
Development of next-generation sequencing and metagenomics has revolutionized detection of novel viruses. Among these viruses are 3 human protoparvoviruses: bufavirus, tusavirus, and cutavirus. These viruses have been detected in feces of children with diarrhea. In addition, cutavirus has been detected in skin biopsy specimens of cutaneous T-cell lymphoma patients in France and in 1 melanoma patient in Denmark. We studied seroprevalences of IgG against bufavirus, tusavirus, and cutavirus in various populations (n = 840), and found a striking geographic difference in prevalence of bufavirus IgG. Although prevalence was low in adult populations in Finland (1.9%) and the United States (3.6%), bufavirus IgG was highly prevalent in populations in Iraq (84.8%), Iran (56.1%), and Kenya (72.3%). Conversely, cutavirus IgG showed evenly low prevalences (0%-5.6%) in all cohorts, and tusavirus IgG was not detected. These results provide new insights on the global distribution and endemic areas of protoparvoviruses.
- Subjects
NUCLEOTIDE sequencing; METAGENOMICS; PARVOVIRUSES; DIARRHEA in children; MICROBIOLOGY; FECES; SKIN biopsy; CUTANEOUS T-cell lymphoma; MELANOMA; PATIENTS
- Publication
Emerging Infectious Diseases, 2018, Vol 24, Issue 7, p1292
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2407.172128