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- Title
Amide Proton Transfer Imaging in Clinics: Basic Concepts and Current and Future Use in Brain Tumors and Stroke.
- Authors
Ji Eun Park; Geon-Ho Jahng; Ha-Kyu Jeong
- Abstract
Amide proton transfer (APT) imaging is gaining attention as a relatively new in vivo molecular imaging technique that has higher sensitivity and spatial resolution than magnetic resonance spectroscopy imaging. APT imaging is a subset of the chemical exchange saturation transfer mechanism, which can offer unique image contrast by selectively saturating protons in target molecules that get exchanged with protons in bulk water. In this review, we describe the basic concepts of APT imaging, particularly with regard to the benefit in clinics from the current literature. Clinical applications of APT imaging are described from two perspectives: in the diagnosis and monitoring of the treatment response in brain glioma by reflecting endogenous mobile proteins and peptides, and in the potential for stroke imaging with respect to tissue acidity.
- Subjects
BRAIN tumor genetics; NUCLEAR magnetic resonance spectroscopy; PROTON transfer reactions
- Publication
Journal of the Korean Society of Radiology, 2016, Vol 75, Issue 6, p419
- ISSN
1738-2637
- Publication type
Article
- DOI
10.3348/jksr.2016.75.6.419