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- Title
Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.
- Authors
Sud, Amit; Thomsen, Hauke; Law, Philip J.; Försti, Asta; da Silva Filho, Miguel Inacio; Holroyd, Amy; Broderick, Peter; Orlando, Giulia; Lenive, Oleg; Wright, Lauren; Cooke, Rosie; Easton, Douglas; Pharoah, Paul; Dunning, Alison; Peto, Julian; Canzian, Federico; Eeles, Rosalind; Kote-Jarai, ZSofia; Muir, Kenneth; Pashayan, Nora
- Abstract
Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10−8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10−17), 6q23.3 (rs6928977, P = 4.62 × 10−11), 10p14 (rs3781093, P = 9.49 × 10−13), 13q34 (rs112998813, P = 4.58 × 10−8) and 16p13.13 (rs34972832, P= 2.12 × 10−8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLADRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.
- Publication
Nature Communications, 2017, Vol 8, Issue 12, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-017-00320-1