We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Comprehensive Review on Antimicrobial Potential of Bioactive Amides.
- Authors
Thakral, Samridhi; Singh, Vikramjeet
- Abstract
The discovery of substituted molecules, structure elucidation, elaboration of effective therapeutics and describing the mechanism of action of newer molecules are some of the significant roles of medicinal chemistry. The treatment of infectious disease still abides a salient and challenging problem due to an alliance of aggravating factors like increasing number of multi-drug resistant microbial pathogens and emergence of various infectious diseases etc. The development of potential anti-infective agents having low incidence of side effects, toxicity and emergence of drug resistance, the involvement of amides is highly supported in medicinal compounds. The amide bond is a vital component and most important functional group of various natural products and synthetic drugs. Amide group possess diverse key structural features which assists in alteration of certain physicochemical properties like increases the solubility in comparison to their parent sulphonic/carboxylic acid and assemble the compound resourceful enough to overcome the hindrance of biological system and improves their binding interactions with active site residues of target receptor. The present study compiles a number of available literature reports on development of amide molecules as antimicrobial agents.
- Subjects
AMIDES; SYNTHETIC products; ANTI-infective agents; BIOLOGICAL systems; PHARMACEUTICAL chemistry
- Publication
International Journal of Pharmacy & Life Sciences, 2020, Vol 11, Issue 7, p41
- ISSN
0976-7126
- Publication type
Article