We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
TRYPANOSOMA CRUZI (CEPA CL) PROMOVE PERDA NEURONAL NO PLEXO MIOENTÉRICO DO CÓLON DE RATOS.
- Authors
Lauer Schneider, Larissa Carla; de Araújo, Silvana Marques; Buttow, Nilza Cristina
- Abstract
The parasite protozoa Trypanosoma cruzi is the etiological agent of Chagas's disease. Infection comprises the acute and chronic type. Mortality in the former is more frequent and the organism that survives passes to the undetermined chronic phase. T. gondii within the gastrointestinal tract parasites the intramural nervous system and causes mega-esophagus and mega-colon. No reports in the literature relate neuronal loss of the myo-enteric plexus with infection by strain CL of T. cruzi. Current analysis verifies morphoquantitative alterations in the myo-enteric plexus in rats' distal colon infected with strain CL during the acute and chronic phase of the disease. Twenty rats were divided into four groups: infected with strain CL of T. cruzi during 7 days (Group IA) and its control (Group CA), killed after seven days from the start of the experiment; another infected group (IC), killed after 30 days and its control (CC). Neuronal density and morphometry of the areas of cell bodies of neurons were estimated by Giemsa technique. Quantitative analysis showed a significant decrease in the number of neurons in infected groups IA and IC. In the case of the neuronal profile, atrophy of neurons of group IC was reported when compared to control. Strain CL of T. cruzi causes a de-nerving of the myo-enteric plexus of the colon without causing a neuronal hypertrophy during the thirty days of experimental period.
- Publication
Saúde e Pesquisa, 2016, Vol 9, Issue 2, p235
- ISSN
1983-1870
- Publication type
Article
- DOI
10.17765/1983-1870.2016v9n2p235-242