We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children.
- Authors
Chhangur, Rabia R.; Weeland, Joyce; Overbeek, Geertjan; Matthys, Walter; Castro, Bram; Giessen, Danielle; Belsky, Jay
- Abstract
This study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (DRD4, DRD2, DAT1, MAOA, and COMT) benefited the most from the Incredible Years (IY) parent program. Data were used from a randomized controlled trial including 341 Dutch families with 4- to 8-year-old children (55.7% boys) showing moderate to high levels of problem behavior. IY proved to be most effective in decreasing parent-reported (but not observed) externalizing behavior in boys (but not girls) carrying more rather than fewer dopaminergic plasticity alleles; this Gene × Intervention effect was most pronounced in the case of boys whose parents' manifested the most positive change in parenting in response to the intervention. These results proved robust across a variety of sampling specifications (e.g., intention to treat, ethnicity).
- Subjects
NETHERLANDS; GENETIC engineering research; BEHAVIOR disorders in children; EXTERNALIZING behavior; DOPAMINE; PHENOTYPIC plasticity; PARENT-child relationships; ALLELES; PSYCHOLOGY of boys; GENETICS; CHILD behavior; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; HEALTH outcome assessment; PARENTING; RESEARCH; PHENOTYPES; EVALUATION research; RANDOMIZED controlled trials; NONPROFESSIONAL education
- Publication
Child Development, 2017, Vol 88, Issue 3, p796
- ISSN
0009-3920
- Publication type
journal article
- DOI
10.1111/cdev.12612