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- Title
Bioactive Diepoxy Metabolites and Highly Oxygenated Triterpenoids from Marine and Plant-Derived Bacteria and Fungi.
- Authors
Dembitsky, Valery M.
- Abstract
This article explores the diverse array of biologically active compounds derived from microbial symbionts, particularly focusing on the isolation and characterization of diepoxides, highly oxygenated triterpenoids, secosteroids, ergostane-type steroids, and meroterpenoids from various marine and plant-derived fungi. We highlight significant discoveries such as vitamin D variants from fungal species, unique sesterterpenoids from mangrove endophytic fungi, and secosteroids with potential medicinal applications. The study delves into the structural uniqueness and bioactivities of these compounds, including their anti-inflammatory, antibacterial, antifungal, antiviral, and cytotoxic effects. Notable findings include the isolation of compounds with significant activity against cancer cell lines, the inhibition of acetylcholinesterase, and promising antifouling properties. This work underscores the potential of microbial symbionts as a rich source of novel bioactive compounds with diverse therapeutic applications, highlighting the importance of marine and fungal biodiversity in drug discovery and development.
- Subjects
MARINE bacteria; TRITERPENOIDS; ENDOPHYTIC fungi; BIOACTIVE compounds; DRUG discovery; MARINE fungi; METABOLITES
- Publication
Microbiology Research, 2024, Vol 15, Issue 1, p66
- ISSN
2036-7481
- Publication type
Article
- DOI
10.3390/microbiolres15010005