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- Title
Potential Utility of Peripherally Applied Loperamide in Oral Chronic Graft-versus-host Disease Related Pain.
- Authors
Nozaki-Taguchi, Natsuko; Shutoh, Mariko; Shimoyama, Naohito
- Abstract
Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects. Current results suggest that the mu-opioid agonist, loperamide, has a potential analgesic effect that could be clinically used as a peripheral analgesic agent for stomatits pain. However, these observations will need to be further confirmed in a randomized-controlled trial.
- Publication
Japanese Journal of Clinical Oncology, 2008, Vol 38, Issue 12, p857
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyn110