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- Title
How Well Do Current Laboratory Biomarkers Inform Clinical Decision-Making in Chronic Pain Management?
- Authors
Hagedorn, Jonathan M; Gunn, Joshua; Budwany, Ryan; D'Souza, Ryan S; Chakravarthy, Krishnan; Deer, Timothy R
- Abstract
While much of the pain biomarker research utilizing CSF, serum, and plasma has focused on genomic, proteomic, and/or transcriptomic targets,39-43 much of the pioneering work involving urine has focused on metabolomic targets.44-46 Deer et al detailed the findings of a retrospective, observational study, which evaluated the prevalence of abnormal metabolomic biomarker findings in a cohort of 17,834 chronic pain patients. Another study by Aurer et al measured inflammatory markers in the saliva from 9 edentulous patients, 10 chronic periodontitis patients, 18 aggressive periodontitis patients, and 14 health control patients.[86] Decreased levels of C-reactive protein (CRP) and alpha-2-macroglobulin (alpha-2M) were detected in edentulous patients and patients with chronic periodontitis. HT <table><tbody><tr><td><graphic href="cr data/article fulltext/s311000/311974/img/JPR A 311974 t0004 Thumb.jpg" content-type="Graph" /></td><td><bold>Table 4</bold> Cerebrospinal Fluid Biomarkers and Relevance in Chronic Pain Pathology</td></tr></tbody></table> ht Wahlbeck et al compared levels of angiotensin converting enzyme (ACE) and arginine vasopressin (AVP) between 15 patients with chronic pain disorder and 19 healthy control patients.[70] Serum AVP levels were significantly higher in chronic pain patients versus healthy controls.
- Subjects
FIBROMYALGIA; PAIN management; CHRONIC pain; GLIAL cell line-derived neurotrophic factor; C-kit protein; NEURAL cell adhesion molecule
- Publication
Journal of Pain Research, 2021, Vol 14, p3695
- ISSN
1178-7090
- Publication type
Article
- DOI
10.2147/JPR.S311974