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- Title
Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls.
- Authors
Sweeten, Thayne L.; Croen, Lisa A.; Windham, Gayle C.; Odell, J. Dennis; Stubbs, E. Gene; Torres, Anthony R.
- Abstract
Previous research indicates that infection, especially from viruses in the family Herpesviridae, may play a role in the etiology of some cases of autism spectrum disorder (ASD). Using a case-control design and the polymerase chain reaction with site-specific primers, we screened newborn and childhood blood samples for the presence of eight human herpesviruses. Herpesvirus DNA was detected in 4 of 225 ASD individuals and 2 of 235 controls, with the most frequently detected virus being HHV-6B. Although this study does not detect a significant ASD-Herpesviridae association, it is limited by the use of site-specific primers. We suggest that new techniques using bioinformatics to search next-generation sequencing databases will be more revealing of possible ASD-virus associations.
- Subjects
AUTISM; HERPESVIRUS diseases; NEWBORN screening; POLYMERASE chain reaction; BIOINFORMATICS; CASE-control method; SEQUENCE analysis; CHILDREN; DIAGNOSIS
- Publication
Journal of Autism & Developmental Disorders, 2019, Vol 49, Issue 1, p410
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-018-3691-x