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- Title
Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica.
- Authors
Rahbar, Mohammad; Samms-Vaughan, Maureen; Loveland, Katherine; Pearson, Deborah; Bressler, Jan; Chen, Zhongxue; Ardjomand-Hessabi, Manouchehr; Shakespeare-Pellington, Sydonnie; Grove, Megan; Beecher, Compton; Bloom, Kari; Boerwinkle, Eric
- Abstract
Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case-control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant ( p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM.
- Subjects
JAMAICA; AUTISM risk factors; AUTISM; CONFIDENCE intervals; EPIDEMIOLOGY; FATHERS; AGE factors in human reproduction; MATERNAL age; MULTIVARIATE analysis; QUESTIONNAIRES; REGRESSION analysis; RESEARCH funding; LOGISTIC regression analysis; DATA analysis; CASE-control method; DATA analysis software; STATISTICAL models; DESCRIPTIVE statistics; CHILDREN
- Publication
Journal of Autism & Developmental Disorders, 2012, Vol 42, Issue 9, p1928
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-011-1438-z