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- Title
Long-term Outcomes Among Older Patients Following Nonmyeloablative Conditioning and Allogeneic Hematopoietic Cell Transplantation for Advanced Hematologic Malignancies.
- Authors
Sorror, Mohamed L.; Sandmaier, Brenda M.; Storer, Barry E.; Franke, Georg N.; Laport, Ginna G.; Chauncey, Thomas R.; Agura, Edward; Maziarz, Richard T.; Langston, Amelia; Hari, Parameswaran; Pulsipher, Michael A.; Bethge, Wolfgang; Sahebi, Firoozeh; Bruno, Benedetto; Maris, Michael B.; Yeager, Andrew; Petersen, Finn Bo; Vindeløv, Lars; McSweeney, Peter A.; Hübel, Kai
- Abstract
The article discusses a study of the outcomes among patients aged 60 years or older after non-myeloablative conditioning and allogeneic hematopoietic cell transplantation (HCT) for advanced hematologic malignancies (AHM). The authors enrolled 372 patients in multicenter, prospective clinical trials of allogeneic HCT for AHM, at 18 centers coordinated through the Fred Hutchinson Cancer Research Center in Seattle, Washington. They calculated the cumulative incidence values for acute and chronic graft-vs-host disease, toxicities, relapse and nonrelapse mortality. They found that there was an association between risks for relapse and worse outcomes.
- Subjects
CELL transplantation; HEMATOLOGIC malignancies; TRANSPLANTATION of organs, tissues, etc.; GRAFT versus host disease; HOMOGRAFTS; BONE marrow transplant complications
- Publication
JAMA: Journal of the American Medical Association, 2011, Vol 306, Issue 17, p1874
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2011.1558