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- Title
Biological variation of serum iron from the European biological variation study (EuBIVAS).
- Authors
Carobene, Anna; Aarsand, Aasne K.; Coşkun, Abdurrahman; Díaz-Garzón, Jorge; Locatelli, Massimo; Fernandez-Calle, Pilar; Sandberg, Sverre; Ceriotti, Ferruccio
- Abstract
Iron in fact, when suspecting iron deficient anemia, should not be measured alone as a test of first level, but together with other markers of iron deficiency like serum ferritin, the most sensitive and specific test to identify isolated iron deficiency, as it reflects low iron stores [[14]]. In summary, our study provides updated BV data for iron derived from the large-scale EuBIVAS and can be used as aid in setting APS and other BV applications for iron. Keywords: analytical performance specification; biological variation; EuBIVAS; iron EN analytical performance specification biological variation EuBIVAS iron e57 e60 4 01/30/23 20230301 NES 230301 To the Editor, Over the last 20 years, the physiology of iron trafficking and metabolism has been thoroughly studied. However, we could not demonstrate any correlation between the personal intra-individual variation (CVp, calculated as proposed in [[15]]) of iron with serum iron concentrations or to CVp of transferrin or of soluble transferrin receptor (data not shown).
- Subjects
BIOLOGICAL variation; IRON; FERRITIN; IRON deficiency anemia
- Publication
Clinical Chemistry & Laboratory Medicine, 2023, Vol 61, Issue 3, pe57
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2022-1091