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- Title
Determination of individual bile acids in acute respiratory distress syndrome reveals a specific pattern of primary and secondary bile acids and a shift to the acidic pathway as an adaptive response to the critical condition.
- Authors
Harnisch, Lars-Olav; Mihaylov, Diana; Bein, Thomas; Apfelbacher, Christian; Kiehntopf, Michael; Bauer, Michael; Moerer, Onnen; Quintel, Michael
- Abstract
Above that, sequential testing could help estimate the course of the disease in terms of resolution (bile acid profile returns to normal) or deterioration (bile acid profile displays the specific adaptive response further or even changes to a "maladaptive profile" most likely reflected by increases in secondary bile acids) of the disease. Currently, it is unknown whether mentioned treatment measures interfere with bile acid metabolism (detectable as cholestasis/increased levels of bile acid in serum) or rather a specific adaptive regulatory response leads to such a specific bile acid pattern. Keywords: acidic pathway; adaptive response; ARDS; bile acid pattern; bile acids EN acidic pathway adaptive response ARDS bile acid pattern bile acids 891 900 10 05/12/22 20220501 NES 220501 Introduction Cholestasis, defined as impaired or blocked bile flow from the liver, is a common finding in approximately 20% of critically ill patients [[1]], [[2]], [[3]].
- Subjects
ADULT respiratory distress syndrome; BILE acids; BILE; CONDITIONED response; ENTEROHEPATIC circulation; GLUCAGON-like peptide-1 agonists; FARNESOID X receptor
- Publication
Clinical Chemistry & Laboratory Medicine, 2022, Vol 60, Issue 6, p891
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2021-1176