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- Title
Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate.
- Authors
Ahmad Nisar, Nisar; Sultana, Mudasir; Ashraf Waiz, Hina; Ahmad Para, Parveez; Ahmad Baba, Naseer; Ahmad Zargar, Fayaz; Hussain Raja, Waseem
- Abstract
Aim : To evaluate the effects of chlorpyriphos, lead acetate, vitamin C alone, and in combination on the activity of oxidative stress parameters in wistar rats. Marerial and Methods: Rats of 150-200g body weight were divided into eight groups of six animals each and were subjected to various daily oral treatment regimes for 98 days. Group I served as control receiving only corn oil, group II received chlorpyriphos @ 5.5 mg/ kg in corn oil, group III received lead acetate @100 ppm in water, whereas animals in group IVth received a combination of chlorpyriphos @ 5.5mg/kg in corn oil and lead acetate @ 100 ppm in water. Group Vth received vitamin C @ 100mg/kg in water, group VIth received a combination of chlorpyriphos @ 5.5mg/kg and vitamin C @ 100mg/kg , group VIIth received lead acetate @ 100 ppm in water and vitamin C @ 100mg/kg and group VIIIth received chlorpyriphos @ 5.5mg/kg , lead acetate @100ppm in water and vitamin C @ 100mg/kg. Results: Administration of both chlorpyriphos and lead acetate caused a significant decrease in oxidative stress parameters viz. blood glutathione, catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST) along with a significant increase in lipid peroxidation level when given alone or in combination. Conclusions: The study demonstrated that treatment of chlorpyriphos and lead treated rats with vitamin C significantly improved some of altered oxidative stress parameters revealing the protective effect of this vitamin C against oxidative stress induced by chlorpyriphos and lead.
- Subjects
VITAMIN C; LIPID peroxidation (Biology); ANTIOXIDANTS; ACETATES; GLUTATHIONE
- Publication
Veterinary World, 2013, Vol 6, Issue 8, p461
- ISSN
0972-8988
- Publication type
Article
- DOI
10.5455/vetworld.2013.461-466