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- Title
Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice.
- Authors
Kashiwagi, Mitsuaki; Kanuka, Mika; Tanaka, Kaeko; Fujita, Masayo; Nakai, Ayaka; Tatsuzawa, Chika; Kobayashi, Kazuto; Ikeda, Kazutaka; Hayashi, Yu
- Abstract
Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockout of tyrosine hydroxylase and its specific rescue in noradrenergic and adrenergic neurons. We found that DD mice have reduced time spent in wakefulness. Unexpectedly, DD mice also exhibited a marked reduction in the time spent in rapid eye movement (REM) sleep. The electroencephalogram power spectrum of all vigilance states in DD mice were also affected. These results support the current understanding of the critical roles of the dopaminergic system in maintaining wakefulness and also implicate its previously unknown effects on REM sleep.
- Subjects
RAPID eye movement sleep; WAKEFULNESS; NON-REM sleep; NORADRENERGIC neurons; TYROSINE hydroxylase; MICE
- Publication
Molecular Brain, 2021, Vol 14, Issue 1, p1
- ISSN
1756-6606
- Publication type
Article
- DOI
10.1186/s13041-021-00879-3