We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluating subjective domains of antipsychotic-induced adverse effects using heart rate variability.
- Authors
Chang, Jae Seung; Hwang, Samuel Suk ‐ Hyun; Yi, Sang Hoon; Kim, Yeni; Lee, Yu ‐ Sang; Kim, Yong Sik; Jung, Hee ‐ Yeon
- Abstract
Aims: Antipsychotic-induced autonomic dysregulation may lead to a wide range of subjective sideeffects in schizophrenia patients. Using heart rate variability (HRV) measures, we prospectively examined the relationship between subjective side-effects and cardiac autonomic regulation in unmedicated schizophrenia patients. Methods: Forty-five unmedicated schizophrenia patients were assessed for antipsychotic-associated side-effects and HRV parameters at baseline and after 6 weeks of treatment. Psychiatric symptoms and subjective side-effects were assessed using the Positive and Negative Syndrome Scale (PANSS) and the Liverpool University Neuroleptic Side-effect Rating Scale (LUNSERS). Results: Correlations between subjective adverse effects and HRV measures at baseline and at week 6 varied. Nonetheless, the changes in the psychic sideeffects domain were significantly correlated with the changes in time-domain HRV measures and sample entropy (SampEn). In addition, the change in SampEn was significantly associated with that in the scores of extrapyramidal, anticholinergic, miscellaneous, and red herring domains as well as the mean total LUNSERS score. Conclusion: Baseline HRV measures may predict clinical response and adverse events associated with treatment adherence. Also, subjective side-effects may correspond well with the changes in neurocardiac dynamics, and the changes in SampEn may effectively reflect subjective discomfort in patients receiving antipsychotic treatment.
- Subjects
HEART beat; PEOPLE with schizophrenia; ANTIPSYCHOTIC agents; DRUG efficacy; SCHIZOPHRENIA treatment
- Publication
Psychiatry & Clinical Neurosciences, 2015, Vol 69, Issue 5, p283
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1111/pcn.12226