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- Title
Slice orientation and muscarinic acetylcholine receptor activation determine the involvement of N-methyl D-aspartate receptor subunit GluN2B in hippocampal area CA1 long-term depression.
- Abstract
The article presents a study focusing on how slice orientation and muscarinic acetylcholine receptor activation determines the involvement of N-methyl D-aspartate receptor (NMDAR) subunit GluN2B in hippocampal area CA1 long-term depression. It states that the results of the study suggest a novel form of NMDAR modulation by mAChRs and clarify some disagreement in the literature. The study also shows that antagonism of muscarinic acetylcholine receptors (mAChRs) in the sagittal slices returned long-term depression (LTD) to a GluN2B-dependent form and enhanced the relation of GluN2B with RasGRF1.
- Subjects
TISSUE slices; MUSCARINIC agonists; ASPARTATE receptors; MUSCARINIC receptors; CHOLINERGIC receptors; SAGITTAL curve; HIPPOCAMPUS (Brain); CHOLINERGIC mechanisms; NEUROTRANSMITTER receptors
- Publication
Molecular Brain, 2011, Vol 4, Issue 1, p41
- ISSN
1756-6606
- Publication type
Article
- DOI
10.1186/1756-6606-4-41