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- Title
Role of TGF-beta on cardiac structural and electrical remodeling.
- Authors
Ramos-Mondragón R; Galindo CA; Avila G; Ramos-Mondragón, Roberto; Galindo, Carlos A; Avila, Guillermo
- Abstract
The type beta transforming growth factors (TGF-betas) are involved in a number of human diseases, including heart failure and myocardial arrhythmias. In fact, during the last 20 years numerous studies have demonstrated that TGF-beta affects the architecture of the heart under both normal and pathological conditions. Moreover, TGF-beta signaling is currently under investigation, with the aim of discovering potential therapeutic roles in human disease. In contrast, only few studies have investigated whether TGF-beta affects electrophysiological properties of the heart. This fact is surprising since electrical remodeling represents an important substrate for cardiac disease. This review discusses the potential role of TGF-beta on cardiac excitation-contraction (EC) coupling, action potentials, and ion channels. We also discuss the effects of TGF-beta on cardiac development and disease from structural and electrophysiological points of view.
- Publication
Vascular Health & Risk Management, 2008, Vol 4, Issue 6, p1289
- ISSN
1176-6344
- Publication type
journal article