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- Title
Mycoplasma pneumoniae Extract Induces an IL-17-Associated Inflammatory Reaction in Murine Lung: Implication for Mycoplasmal Pneumonia.
- Authors
Kurai, Daisuke; Nakagaki, Kazuhide; Wada, Hiroo; Saraya, Takeshi; Kamiya, Shigeru; Fujioka, Yasunori; Nakata, Koh; Takizawa, Hajime; Goto, Hajime
- Abstract
Mycoplasma pneumoniae (Mp) may cause immune cell reactions as pivotal aspects of this clinically common respiratory pathogen. Our aim is to determine if Mp extract induces a cellular immune response associated with interleukin (IL)-17, leading to lung inflammation and lung injury. BALB/c mice were immunized with Mp extract intraperitoneally followed by its intratracheal administration, to mimic repeated Mp infection found in humans (repeated inoculation, RI group). Those with a single inoculation were compared as single inoculation group (SI group). Analysis of bronchoalveolar lavage fluid (BALF) demonstrated that keratinocyte-derived cytokine, tumor necrosis factor-α, and IL-6 were produced and peaked on days 0.5 or 1, followed by IL-17 on day 2. Levels of these mediators in BALF were higher in RI group than SI group ( P < 0.05). Further, significantly more neutrophils were recruited to the lungs of the RI group ( P < 0.05). These observations suggest that IL-17 is involved in the prolonged induction of neutrophils in mice treated with Mp extract.
- Subjects
INFLAMMATION treatment; MYCOPLASMA pneumoniae infections; PLANT extracts; IMMUNE response; INTERLEUKIN-17; DRUG administration; LABORATORY mice
- Publication
Inflammation, 2013, Vol 36, Issue 2, p285
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-012-9545-3