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- Title
Transition Metal‐Free C5 Tosyloxylation of 8‐Aminoquinolines with Phenyliodine Bistrifluoroacetate and Substituted 1,2‐Disulfonyl Hydrazides.
- Authors
Liang, Tingting; He, Xin; Ji, Dezhong; Wu, Huanhuan; Xu, Yizhu; Li, Yuyan; Wang, Zhibin; Xu, Yungen; Zhu, Qihua
- Abstract
A novel and efficient method for direct tosyloxylation at C5 position of 8‐aminoquinolines has been accomplished by nonmetal‐catalyzed C–H functionalization at mild conditions. It is shown, for the first time, that the radical RSO3· could be generated by the reaction of phenyliodine bistrifluoroacetate with substituted 1,2‐disulfonyl hydrazides. This reaction reveals excellent reactivity, good functional group tolerance, and moderate to good yield.
- Subjects
HYDRAZIDES; FUNCTIONAL groups
- Publication
European Journal of Organic Chemistry, 2019, Vol 2019, Issue 14, p2513
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201900092