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- Title
Expression of Concern: Novel Split-Luciferase-Based Genetically Encoded Biosensors for Noninvasive Visualization of Rho GTPases.
- Abstract
Specifically, The following Fig 4B panels appear similar: CDC42 biosensors WB FC-Rho, CDC42 biosensors CoIP FN-WASP when rotated 180°, and RhoA biosensors CoIP FN-PAK when flipped horizontally The following Fig 4B panels appear to partially overlap with one another: Rac1 biosensors WB FC-Rho, RhoA biosensors WB FC-Rho, and RhoA biosensors WB GAPDH when rotated 180° The following Fig 6A panels appear similar: Active RhoA, active Rac1, and active CDC42 when rotated 180° and vertically compressed The corresponding author commented that errors were made during figure preparation, due to the similarities in bands and overall underlying images. The corresponding author also clarified that during their post-publication review of the data, they noticed that the following published panels were also incorrect: Fig 4B CDC42 biosensors WB FN-WASP Fig 4B Rac1 biosensors CoIP FN-PKN Fig 4B RhoA biosensors WB FN-PAK Graph: Fig 4 The application of BiLC strategy to image the three main members of Rho GTPases.The results of optical imaging of three kinds of BiLC RhoGTPase biosensors. Graph: Fig 6 The sensitivity analysis of BiLC Rho GTPase sensors to extracellular ligands.(A) The temporal response of BiLC Rho GTPase sensors stimulated by extracellular ligands.
- Subjects
RHO GTPases; DATA visualization; RENILLA luciferase; EMISSION exposure
- Publication
PLoS ONE, 2023, Vol 17, Issue 6, p1
- ISSN
1932-6203
- Publication type
Correction Notice
- DOI
10.1371/journal.pone.0287871