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- Title
Extracellular regulation of BMP signaling: welcome to the matrix.
- Authors
Sedlmeier, Georg; Sleeman, Jonathan P.
- Abstract
Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling.
- Subjects
BONE morphogenetic proteins; EXTRACELLULAR enzymes; EXTRACELLULAR matrix; PROTEIN expression; CELLULAR control mechanisms
- Publication
Biochemical Society Transactions, 2017, Vol 45, Issue 1, p173
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20160263