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- Title
Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages
- Authors
Gómez-Muñoz, Antonio; Kong, Jennifer; Salh, Bill; Steinbrecher, Urs P.
- Abstract
Sphingosine-1-phosphate (Sph-1-P) regulates critical cellular functions including cell proliferation, differentiation, angiogenesis, and cell survival. However, its mechanisms of action are incompletely understood. Here, we show a novel biological effect of Sph-1-P: inhibition of acidic sphingomyelinase (A-SMase) activity in apoptotic bone marrow-derived macrophages. A-SMase catalyzes the conversion of sphingomyelin to ceramides, which are pro-apoptotic. This action of Sph-1-P prevents the accumulation of ceramides and blocks apoptosis, thereby promoting survival of the macrophages.
- Subjects
MACROPHAGES; SERUM
- Publication
FEBS Letters, 2003, Vol 539, Issue 1-3, p56
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)00197-2