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- Title
Cyclin destruction in mitosis: a crucial task of Cdc20
- Authors
Irniger, Stefan
- Abstract
Proteolytic destruction of cyclins is a fundamental process for cell division. At the end of mitosis, degradation of mitotic cyclins results in the inactivation of cyclin-dependent kinases. Cyclin proteolysis is triggered by the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit complex which contains ubiquitin ligase activity. Recent data in yeast demonstrated that a partial degradation of the mitotic cyclin Clb2, mediated by APC/C and its activator protein Cdc20, is essential and sufficient for the mitotic exit. Remarkably, a complete inactivation of cyclin-dependent kinases seems to be not essential. This review discusses recent novel insights into cyclin destruction and its implications for the mitotic exit.
- Subjects
CYCLINS; MITOSIS
- Publication
FEBS Letters, 2002, Vol 532, Issue 1/2, p7
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)03657-8