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- Title
Evaluation of Magnetic Hyperthermia Efficiency of PEG-Coated Fe<sub>3</sub>O<sub>4</sub> Nanoparticles.
- Authors
Srivastava, Neha; Baranwal, Manoj; Chudasama, Bhupendra
- Abstract
Magnetic nanoparticle hyperthermia has drawn considerable interest in cancer therapy. In this study, we report the synthesis of PEG-coated Fe3O4 nanoparticles and evaluate their suitability for magnetic hyperthermia applications. Fe3O4 nanoparticles were synthesized by the chemical coprecipitation method, which are coated with polyethylene glycol (PEG). PEG-coated Fe3O4 nanoparticles were characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM), dynamic light scattering (DLS) and transmission electron microscopy (TEM). Synthesized nanoparticles possess inverse-spinel structural with a crystallite size of 9.1 nm. From the M-H hysteresis loops, it was confirmed that the synthesized Fe3O4 nanoparticles were superparamagnetic. The physical size of bare Fe3O4 nanoparticles, as determined from the HR-TEM, is 9. 5 ± 0. 1 2 nm, and the corresponding hydrodynamic size of PEG-coated Fe3O4 nanoparticles is 1 1 8 ± 0. 2 5 nm. Magnetic hyperthermia efficiency of PEG-coated Fe3O4 nanoparticles was determined as a function of magnetic field frequency (162–935.6 kHz), field strength (5–12 mT) and nanoparticle concentration (1–100 mg/mL). Temperature rise in an aqueous dispersion of PEG-coated Fe3O4 nanoparticles was measured for 20 min. The specific loss power (SLP) was calculated by the corrected slope method. SLP values of PEG-coated Fe3O4 nanoparticles increase with magnetic field frequency and field strength and decrease with nanoparticle concentration. The optimum hyperthermia performance of PEG-coated Fe3O4 nanoparticles was observed for 935.6 kHz frequency, 10 mT field strength and 25 mg/mL concentration. Under these conditions, the measured SLP of PEG-coated Fe3O4 nanoparticles was 4.43 W/g. These results show that the synthesized PEG-coated Fe3O4 nanoparticles could be a potential candidate for magnetic hyperthermia treatment of cancer. PEG-coated Fe3O4 nanoparticles were synthesized using a chemical co-precipitation method. The nanoparticle's physio-chemical properties were characterized using X-ray diffraction, transmission electron microscopy, vibrating sample magnetometer, photon correlation, and FTIR spectroscopy. The synthesized nanoparticles' hyperthermia performance was evaluated based on magnetic field frequency (162–935.6 kHz), field strength (5–12 mT), and nanoparticle concentration (1–100 mg/mL).
- Subjects
MAGNETIC nanoparticle hyperthermia; FOURIER transform infrared spectroscopy; X-ray powder diffraction; FEVER; PHOTON correlation; TRANSMISSION electron microscopy
- Publication
NANO, 2023, Vol 18, Issue 12, p1
- ISSN
1793-2920
- Publication type
Article
- DOI
10.1142/S1793292023500947