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- Title
Biomarqueurs sanguins des lésions gastriques pré-néoplasiques.
- Authors
Bazin, Thomas; Nozeret, Karine; Touati, Eliette; Lamarque, Dominique
- Abstract
Currently, gastric pre-neoplastic lesions (glandular atrophy, intestinal metaplasia, dysplasia) can only be detected during an upper GI endoscopy. Depending on their extent and severity, follow-up is proposed in order to detect the appearance of gastric adenocarcinoma as early as possible. When there is no indication for endoscopy, pre-neoplastic lesions may be present and evolve silently. In countries with a low risk of gastric cancer such as France, where there is no systematic endoscopic screening, patients not at high risk of gastric adenocarcinoma in whom pre-neoplastic lesions exist therefore have a loss of chance with a risk of developing gastric adenocarcinoma at a symptomatic stage, with a poor prognosis. Several serum biomarkers of pre-neoplastic lesions have been proposed, deriving from the histological characteristics of these lesions. The TFF3 peptide is a biomarker of intestinal metaplasia, and the pepsinogen I/II ratio of glandular atrophy. The place of these biomarkers in a national screening strategy remains to be clarified.
- Subjects
PRECANCEROUS conditions; PEPTIDES; PEPSINOGEN; DISEASE risk factors; STOMACH cancer
- Publication
Hépato-Gastro & Oncologie Digestive, 2023, Vol 30, Issue 1, p47
- ISSN
2115-3310
- Publication type
Article
- DOI
10.1684/hpg.2023.2516