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- Title
Antibacterial activity of disulfiram and its metabolites.
- Authors
Frazier, K.R.; Moore, J.A.; Long, T.E.
- Abstract
Aims: Disulfiram (Antabuse™) and its metabolites formed in vivo were evaluated as antibacterial agents against thirty species of Gram‐positive and Gram‐negative bacteria. The synergistic potential of disulfiram (DSF) and metabolite diethyldithiocarbamate (DDTC) with approved antibiotics were also compared by isobologram (checkerboard) analysis. Methods and Results: Standard microdilution susceptibility testing showed that most DSF metabolites did not possess appreciable antibacterial activity except for DDTC in Bacillus anthracis. Checkerboard studies revealed similarities between the combination drug effects of DSF and DDTC with standard antibiotics. Conclusions: It was concluded from the susceptibility data that the metabolites would not extend the antibacterial spectrum of DSF in vivo. The data also suggest that the DDTC by‐product of DSF metabolism potentiates the antibacterial activity of DSF as both a standalone and combination agent. Significance and Impact of the Study: The study provides a greater understanding of the antibacterial effects of Antabuse and its metabolites. This research also demonstrates the potential application of DSF as an antibiotic adjuvant for the treatment of resistant staph infections.
- Subjects
DISULFIRAM; ANTIBACTERIAL agents; METABOLITES; DIETHYLDITHIOCARBAMATE; ANTIBIOTICS
- Publication
Journal of Applied Microbiology, 2019, Vol 126, Issue 1, p79
- ISSN
1364-5072
- Publication type
Article
- DOI
10.1111/jam.14094