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- Title
Highly Integrated MEMS-ASIC Sensing System for Intracorporeal Physiological Condition Monitoring.
- Authors
Xue, Ning; Wang, Chao; Liu, Cunxiu; Sun, Jianhai
- Abstract
In this paper, a highly monolithic-integrated multi-modality sensor is proposed for intracorporeal monitoring. The single-chip sensor consists of a solid-state based temperature sensor, a capacitive based pressure sensor, and an electrochemical oxygen sensor with their respective interface application-specific integrated circuits (ASICs). The solid-state-based temperature sensor and the interface ASICs were first designed and fabricated based on a 0.18-μm 1.8-V CMOS (complementary metal-oxide-semiconductor) process. The oxygen sensor and pressure sensor were fabricated by the standard CMOS process and subsequent CMOS-compatible MEMS (micro-electromechanical systems) post-processing. The multi-sensor single chip was completely sealed by the nafion, parylene, and PDMS (polydimethylsiloxane) layers for biocompatibility study. The size of the compact sensor chip is only 3.65 mm × 1.65 mm × 0.72 mm. The functionality, stability, and sensitivity of the multi-functional sensor was tested ex vivo. Cytotoxicity assessment was performed to verify that the bio-compatibility of the device is conforming to the ISO 10993-5:2009 standards. The measured sensitivities of the sensors for the temperature, pressure, and oxygen concentration are 10.2 mV/◦C, 5.58 mV/kPa, and 20 mV.L/mg, respectively. The measurement results show that the proposed multi-sensor single chip is suitable to sense the temperature, pressure, and oxygen concentration of human tissues for intracorporeal physiological condition monitoring.
- Subjects
MICROELECTROMECHANICAL systems; APPLICATION-specific integrated circuits; COMPLEMENTARY metal oxide semiconductors; OXYGEN detectors; ELECTROCHEMICAL sensors; TEMPERATURE sensors
- Publication
Sensors (14248220), 2018, Vol 18, Issue 1, p107
- ISSN
1424-8220
- Publication type
Article
- DOI
10.3390/s18010107