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- Title
Campylobacter pylori and Non-ulcer Dyspepsia.
- Authors
Rokkas, T.; Pursey, C.; Uzoechina, E.; Dorrington, L.; Simmons, N. A.; Filipe, M. I.; Sladen, G. E.
- Abstract
Non-ulcer dyspepsia (NUD) is a poorly understood syndrome often present in association with gastritis. Among patients undergoing gastroscopy, some with NUD have a gastric mucosa colonized by the campylobacter-like organism, <em>Campylobacter pylori</em>. We therefore studied prospectively 55 consecutive patients with NUD and 15 normal controls to determine the prevalence of <em>C. pylori</em> organisms, and to investigate their association with histological gastritis, macroscopic evidence of gastritis, sex, smoking, alcohol consumption, and dyspeptic symptoms. We found a 45.4% prevalence in NUD patients which was statistically significantly higher than the 13.33% prevalence in the control group (<em>p</em> < 0.05). We also found a close association between <em>C. pylori</em> and microscopic evidence of gastritis (<em>p</em> < 0.001), male sex (<em>p</em> < 0.001), and postprandial bloating (<em>p</em> < 0.05). We did not find any significant association between <em>C. pylori</em> and macroscopic evidence of gastritis, smoking, alcohol consumption and other dyspeptic symptoms. Our findings suggest that <em>C. pylori</em> may play a pathogenic role in NUD.
- Subjects
INDIGESTION; HELICOBACTER pylori infections; STOMACH examination; GASTRITIS; PATIENTS
- Publication
American Journal of Gastroenterology (Springer Nature), 1987, Vol 82, Issue 11, p1149
- ISSN
0002-9270
- Publication type
Article