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- Title
Some Implications of the High Intrasynaptic Norepinephrine Concentrations in Resistance Arteries.
- Authors
Bevan, John A.; Laher, Ismail; Rowan, Reed
- Abstract
Norepinephrine concentrations in excess of 10-4M are achieved at the post-junctional membrane of the adrenergic synaptic cleft in resistance arteries at least for short periods of time. These concentrations are greater than the threshold of low affinity non-α-adrenoceptors-'extraceptors', that respond to norepinephrine and would be sufficient to overcome the blockade by α-adrenoceptor antagonists. The relationship of such activity to the excitatory junction potential and the relevance of this to contraction in vivo remains a matter of conjecture. Copyright © 1987 S. Karger AG, Basel
- Publication
Journal of Vascular Research, 1987, Vol 24, Issue 3, p137
- ISSN
1018-1172
- Publication type
Article
- DOI
10.1159/000158687