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- Title
Foxp3/scurfin Gene Polymorphism in 'Adult' Type 1 Diabetes in Japanese.
- Authors
Iwase, Kyoko; Kawai, Toshihide; Kanazawa, Yasuhiko; Okubo, Yoshiaki; Oikawa, Yoichi; Maruyama, Taro; Shimada, Akira; Ito, Hiroshi
- Abstract
Type 1 diabetes is considered as autoimmune disease targeted at pancreatic β cells. Recent data indicate the involvement of regulatory T cell (Treg) dysfunction in type 1 diabetes. Foxp3 is considered as a master gene of Tregs, and very recent data has shown the relationship between type 1 diabetes and (GT)n polymorphism of Foxp3/Scurfin gene in Japanese children. There is controversy regarding the 'child-hood' type 1 diabetes and 'adult onset' type 1 diabetes, therefore, we investigated the relationship between type I diabetes and (GT)n polymorphism of Foxp3/Scurfin gene in Japanese adults. We recruited type I diabetic patients (64 male, 70 female) and controls (61 male, 35 female), obtained an informed consent for this study, and (GT)n of Foxp3/Scurfin gene polymorphism was analyzed. Frequency of (GT)[sub 15] was 47.1% and 74.3%, (GT)[sub 16] was 40.1% and 60.3%, in overall type 1 diabetes and controls, respectively; i.e. we found no significant difference between the two groups. Moreover, even though we analyzed the data by allocating the type 1 diabetic patients to subgroups (acute or slow onset type, GAD Ab(+) or (-)), we found no difference when compared to controls. In conclusion, we found no correlation between the Foxp3/Scurfin gene polymorphism and 'adult' type 1 diabetes in Japanese.
- Subjects
GENETICS of diabetes; GENETIC polymorphisms; T cells; PEOPLE with diabetes; JAPANESE people; DISEASES
- Publication
Diabetes, 2007, Vol 56, pA288
- ISSN
0012-1797
- Publication type
Article